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Polyunsaturated fatty acid status and markers of oxidative stress and inflammation across the lifespan: A cross-sectional study in a cohort with long-lived individuals.
- Source :
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Experimental gerontology [Exp Gerontol] 2024 Oct 01; Vol. 195, pp. 112531. Date of Electronic Publication: 2024 Jul 31. - Publication Year :
- 2024
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Abstract
- Polyunsaturated fatty acids (PUFA) are known to have a regulatory effect on oxidative and inflammatory processes. This study aimed to identify the relationship between blood PUFA status and circulatory markers of oxidative stress and inflammation in a cohort of 172 subjects. The population was divided by sex and into three age groups: adults (18-64 years old, n = 69), older adults (65-89 years old, n = 54), and long-lived individuals (LLIs, 90-111 years old, n = 49). Whole blood PUFA content was quantified using gas chromatography. Additionally, serum levels of C-reactive protein (CRP), paraoxonase (PON), Trolox equivalent antioxidant capacity (TEAC), and malondialdehyde (MDA) were measured. Our results showed that a higher omega-3 (n-3) index in adult females was a predictor of lower MDA concentrations (p = 0.038). Conversely, total n-3 PUFA and total n-6 PUFA were positively related to MDA values among older adult females and LLI men (p < 0.05), while total n-6 PUFA was inversely correlated with MDA levels in LLI females (p < 0.05). Interestingly, increased concentrations of total n-3 PUFA and n-3 index were positively correlated with higher TEAC values in LLI men (p = 0.007), while the arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio was inversely correlated with TEAC values among LLI females (p = 0.006). These findings suggest that cellular antioxidant capacity is inversely correlated with changes in the AA/EPA ratio in long-lived females, whereas n-3 PUFA may enhance blood antioxidant capacity in long-lived men. Overall, our study highlights the complex, sex-specific interactions between PUFA profiles and oxidative stress and inflammatory markers across different age groups.<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Female
Male
Middle Aged
Aged
Adult
Cross-Sectional Studies
Aged, 80 and over
Young Adult
C-Reactive Protein analysis
C-Reactive Protein metabolism
Adolescent
Fatty Acids, Omega-3 blood
Aryldialkylphosphatase blood
Antioxidants metabolism
Antioxidants analysis
Aging blood
Oxidative Stress
Biomarkers blood
Inflammation blood
Longevity physiology
Malondialdehyde blood
Fatty Acids, Unsaturated blood
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6815
- Volume :
- 195
- Database :
- MEDLINE
- Journal :
- Experimental gerontology
- Publication Type :
- Academic Journal
- Accession number :
- 39079651
- Full Text :
- https://doi.org/10.1016/j.exger.2024.112531