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In vitro interactions of combinations of colistin with meropenem, rifampicin and tigecycline in colistin-resistant, biofilm-forming Klebsiella pneumoniae.
- Source :
-
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Oct; Vol. 110 (2), pp. 116408. Date of Electronic Publication: 2024 Jun 20. - Publication Year :
- 2024
-
Abstract
- In this study, it was aimed to reveal the in vitro interactions of combinations of colistin with meropenem, rifampicin and tigecycline in colistin-resistant, biofilm-forming Klebsiella pneumonia. A total of 30 isolates, 15 of which formed biofilms and 15 did not form biofilms, were randomly selected from K. pneumoniae isolates growing in blood samples. The synergy rates of colistin-meropenem, colistin-tigecycline, colistin-rifampicin combinations in planktonic/sessile bacteria are; It was determined as 83,3%/73,3%, 66,6%/33,3%, 100%/60% respectively. Biofilm inhibitory concentration (BIC) of colistin, meropenem, tigecycline, and rifampicin significantly increased after biofilm formation. The synergistic activity seen in the sessile form was independent of the planktonic form. Although a high synergistic effect was observed in the meropenem-colistin combination on sessile bacteria, colistin had very high BIC in all combinations. Large-scale studies are needed in which the number of isolates studied is large, bacterial resistance profiles are evaluated genomically, and various antimicrobial groups are included.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Drug Resistance, Bacterial
Klebsiella pneumoniae drug effects
Biofilms drug effects
Colistin pharmacology
Tigecycline pharmacology
Rifampin pharmacology
Meropenem pharmacology
Anti-Bacterial Agents pharmacology
Microbial Sensitivity Tests
Drug Synergism
Klebsiella Infections microbiology
Klebsiella Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0070
- Volume :
- 110
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diagnostic microbiology and infectious disease
- Publication Type :
- Academic Journal
- Accession number :
- 39079190
- Full Text :
- https://doi.org/10.1016/j.diagmicrobio.2024.116408