Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children.

Authors :: Kobbe R
Rau C
Schulze-Sturm U
Stahl F
Fonseca-Brito L
Diemert A
Lütgehetmann M
Addo MM
Arck P
Weskamm LM
Source :: The Pediatric infectious disease journal [Pediatr Infect Dis J] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: Humoral immune responses after BNT162b2 vaccination are predominantly composed of immunoglobulin (Ig) G1 and IgG3 subclass antibodies. As previously described in adults, S1-specific and receptor-binding domain-specific IgG4 levels increase significantly 1 year after the second BNT162b2 vaccination in children 5-11 years of age. Understanding mRNA vaccine-specific IgG4 responses in all age groups is crucial as more mRNA vaccines will reach licensure in the coming years.<br /> (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

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