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Multiple cognition associated multimodal brain networks in major depressive disorder.
Multiple cognition associated multimodal brain networks in major depressive disorder.
- Source :
-
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Jul 03; Vol. 34 (7). - Publication Year :
- 2024
-
Abstract
- Major depressive disorder frequently leads to cognitive impairments, significantly affecting patients' quality of life. However, the neurobiological mechanisms underlying cognitive deficits remain unclear. This study aimed to explore multimodal imaging biomarkers associated with cognitive function in major depressive disorder. Five cognitive scores (sustained attention, visual recognition memory, pattern recognition memory, executive function, and working memory) were used as references to guide the fusion of gray matter volume and amplitude of the low frequency fluctuation. Social function was assessed after 2 yr. Linear regression analysis was performed to identify brain features that were associated with social function of patients with major depressive disorder. Finally, we included 131 major depressive disorder and 145 healthy controls. A multimodal frontal-insula-occipital network associated with sustained attention was found to be associated with social functioning in major depressive disorders. Analysis across different cognitive domains revealed that gray matter volume exhibited greater sensitivity to differences, while amplitude of the low frequency fluctuation consistently decreased in the right temporal-occipital-hippocampus circuit. The consistent functional changes across the 5 cognitive domains were related to symptom severity. Overall, these findings provide insights into biomarkers associated with multiple cognitive domains in major depressive disorder. These results may contribute to the development of effective treatment targeting cognitive deficits and social function.<br /> (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Humans
Female
Male
Adult
Middle Aged
Gray Matter diagnostic imaging
Gray Matter pathology
Gray Matter physiopathology
Neuropsychological Tests
Multimodal Imaging
Executive Function physiology
Attention physiology
Young Adult
Nerve Net diagnostic imaging
Nerve Net physiopathology
Depressive Disorder, Major diagnostic imaging
Depressive Disorder, Major physiopathology
Magnetic Resonance Imaging
Brain diagnostic imaging
Brain physiopathology
Cognition physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2199
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Publication Type :
- Academic Journal
- Accession number :
- 39077922
- Full Text :
- https://doi.org/10.1093/cercor/bhae305