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Case report: Characterization of the immunologic and molecular landscape in a unique presentation of invasive lobular carcinoma with concurrent uterine carcinosarcoma treated with immunotherapy.
- Source :
-
Frontiers in immunology [Front Immunol] 2024 Jul 15; Vol. 15, pp. 1422342. Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Invasive lobular breast cancer (ILC) is characterized by a relatively high risk for late recurrence and a unique metastatic pattern with an increased risk for metastasis to gynecologic organs and peritoneum. We present a unique case of recurrent ILC with metastasis to the abdominal peritoneum as well as the uterine myometrium and cervix. Treatment was complicated by the discovery of concomitant uterine carcinosarcoma. This patient was effectively treated with a combination of hormonal therapy for her metastatic ILC and a combination of chemotherapy and immunotherapy for uterine carcinosarcoma. Molecular evaluation revealed a characteristic CDH1 mutation within the ILC and a PI3KCA mutation within the uterine carcinosarcoma, both of which have been linked to epithelial-to-mesenchymal transitions. Examination of the tumor immune microenvironment revealed proportionally more cytotoxic NK cells. This robust immune infiltration may be an indicator of the response to immunotherapy observed in this tumor or a result of the metastatic breast cancer within the uterus. This report provides a characterization of the molecular and immunologic landscape in this case with metastatic ILC and uterine carcinosarcoma.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Riedinger, Eisele, Esnakula, Stover, Freud and Cosgrove.)
- Subjects :
- Humans
Female
Middle Aged
Antigens, CD genetics
Antigens, CD immunology
Mutation
Tumor Microenvironment immunology
Class I Phosphatidylinositol 3-Kinases genetics
Cadherins genetics
Killer Cells, Natural immunology
Carcinosarcoma therapy
Carcinosarcoma immunology
Carcinosarcoma genetics
Uterine Neoplasms therapy
Uterine Neoplasms genetics
Uterine Neoplasms immunology
Uterine Neoplasms pathology
Carcinoma, Lobular immunology
Carcinoma, Lobular therapy
Carcinoma, Lobular secondary
Carcinoma, Lobular genetics
Immunotherapy methods
Breast Neoplasms therapy
Breast Neoplasms immunology
Breast Neoplasms genetics
Breast Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 39076998
- Full Text :
- https://doi.org/10.3389/fimmu.2024.1422342