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Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts.
- Source :
-
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Jul 29; Vol. 9 (1), pp. 179. Date of Electronic Publication: 2024 Jul 29. - Publication Year :
- 2024
- Subjects :
- Humans
Transcription, Genetic drug effects
DNA Replication drug effects
DNA Replication genetics
Poly(ADP-ribose) Polymerases genetics
Poly(ADP-ribose) Polymerases metabolism
Poly(ADP-ribose) Polymerase Inhibitors pharmacology
Poly(ADP-ribose) Polymerase Inhibitors therapeutic use
Synthetic Lethal Mutations genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2059-3635
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Signal transduction and targeted therapy
- Publication Type :
- Academic Journal
- Accession number :
- 39069543
- Full Text :
- https://doi.org/10.1038/s41392-024-01893-2