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Lower plasma tumor necrosis factor-α is associated with symptomatic remission in patients with schizophrenia.
- Source :
-
Journal of psychiatric research [J Psychiatr Res] 2024 Sep; Vol. 177, pp. 299-304. Date of Electronic Publication: 2024 Jul 22. - Publication Year :
- 2024
-
Abstract
- We investigated the plasma tumor necrosis factor (TNF)-α levels between patients with schizophrenia remission and healthy controls, and the association between the plasma TNF-α levels and cognitive function and social function. This cross-sectional study included 48 patients with schizophrenia who fulfilled the remission criteria and 20 healthy controls. Plasma TNF-α levels were measured using the enzyme-linked immunosorbent assay, and cognitive function was assessed using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J). We measured social function using the Social Functioning Scale (SFS-J). The plasma TNF-α levels were significantly lower in the remission schizophrenia group (31.7 ± 27.4 ng/mL) compared to the heathy control group (55.1 ± 38.5 ng/mL) (P = 0.01). In contrast, no correlation was observed between the plasma levels of TNF-α and all BACS-J scores and all SFS-J scores in either group. This result suggests that plasma TNF-α levels may serve as a clinical biomarker of remission of schizophrenia and that the plasma TNF-α levels bore no association with cognitive function. Thus, TNF-α may have potential as a useful indicator of the therapeutic response in patients with schizophrenia.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-1379
- Volume :
- 177
- Database :
- MEDLINE
- Journal :
- Journal of psychiatric research
- Publication Type :
- Academic Journal
- Accession number :
- 39059027
- Full Text :
- https://doi.org/10.1016/j.jpsychires.2024.07.029