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Host-derived lactic acid bacteria alleviate short beak and dwarf syndrome by preventing bone loss, intestinal barrier disruption, and inflammation.
- Source :
-
Veterinary microbiology [Vet Microbiol] 2024 Sep; Vol. 296, pp. 110187. Date of Electronic Publication: 2024 Jul 19. - Publication Year :
- 2024
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Abstract
- Short-beak and dwarf syndrome (SBDS) is caused by novel goose parvovirus (NGPV) infection, which leads to farm economic losses. Our research aimed to investigate the potential of administering isolated lactic acid bacteria (LAB) in alleviating SBDS in ducks. Eight wild LAB strains were isolated from duck feces and their biosecurity was investigated in both duck embryo fibroblast (DEF) and live ducks. Moreover, the LAB strains exhibited no detrimental effects on bone metabolism levels and facilitated the tight junction proteins (TJPs) mRNA expression, and contributing to the mitigation of inflammation in healthy ducks. Subsequently, we conducted in vitrol and in vivo experiments to assess the impact of LAB on NGPV infection. The LAB strains significantly reduced the viral load of NGPV and downregulated the mRNA levels of pro-inflammatory factors in DEF. Additionally, LAB treatment alleviated SBDS in NGPV-infected ducks. Furthermore, LAB treatment alleviated intestinal damage, and reduced the inflammatory response, while also mitigating bone resorption in NGPV-infected ducks. In conclusion, the LAB strains isolated from duck feces have favorable biosecurity and alleviate SBDS in ducks, and the mechanism related to LAB improves intestinal barrier integrity, alleviates inflammation, and reduces bone resorption. Our study presents a novel concept for the prevention and treatment of NGPV, thereby establishing a theoretical foundation for the future development of probiotics in the prevention and treatment of NGPV.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Animals
Parvoviridae Infections veterinary
Parvoviridae Infections prevention & control
Parvoviridae Infections virology
Parvoviridae Infections microbiology
Feces microbiology
Feces virology
Bone Resorption prevention & control
Bone Resorption microbiology
Bone Resorption veterinary
Intestines microbiology
Intestines virology
Probiotics administration & dosage
Probiotics pharmacology
Probiotics therapeutic use
Parvovirus genetics
Geese virology
Ducks virology
Ducks microbiology
Poultry Diseases microbiology
Poultry Diseases prevention & control
Poultry Diseases virology
Inflammation veterinary
Inflammation prevention & control
Lactobacillales genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2542
- Volume :
- 296
- Database :
- MEDLINE
- Journal :
- Veterinary microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 39053390
- Full Text :
- https://doi.org/10.1016/j.vetmic.2024.110187