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Mmu_circ_0005373 and hsa_circ_0136255 participate in the pulmonary fibrosis of systemic sclerosis.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112690. Date of Electronic Publication: 2024 Jul 24. - Publication Year :
- 2024
-
Abstract
- The pathogenesis of SSc pulmonary fibrosis is complex and prognosis is poor. In order to find biomarkers to provide assistance in the diagnosis and treatment of systemic sclerosis (SSc), this study explored the role of SSc-related differentially expressed circRNAs in the fibrosis process. This study explored whether circular RNA (circRNA) mediated the mTOR signaling pathway by interacting with the eukaryotic translation initiation factor eIF4E-binding protein 1 (4E-BP1), participated in a competing endogenous RNA (ceRNA) network, and regulated the mechanism of pulmonary fibrosis in systemic sclerosis (SSc). The results showed that the expression of mmu&#95;circ&#95;0005373 was reduced, and mmu&#95;circ&#95;0005373 may regulate the mTOR signaling pathway by inhibiting the interacting with 4E-BP1 protein in the lung of SSc mice, and promote fibrosis in SSc. Hsa&#95;circ&#95;0136255, which is homologous to mmu&#95;circ&#95;0005373, is also reduced in SSc peripheral blood mononuclear cells, and predicted to interact with 4E-BP1 protein. Hsa&#95;circ&#95;0136255/hsa-miR-330-3p/TNFAIP3 ceRNA network had biological significance in SSc, and correlated with clinical data, including high-resolution CT, average expiratory flow at 25% vital capacity, neutrophil count, lymphocyte percentage, standard deviation of red blood cell distribution width, coefficient of variation of red blood cell distribution width, platelet distribution width, glutamic transaminase, γ-glutamyl transpeptidase, lymphocyte percentage, basophils percentage, red blood cell, plateletcrit, cholinesterase, and mean corpuscular hemoglobin concentration. Hsa&#95;circ&#95;0136255, hsa-miR-330-3p, and TNFAIP3 may be used as biomarkers for clinical diagnosis and treatment of SSc.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Animals
Mice
Adaptor Proteins, Signal Transducing genetics
Adaptor Proteins, Signal Transducing metabolism
Male
Signal Transduction
Female
TOR Serine-Threonine Kinases metabolism
Cell Cycle Proteins genetics
Cell Cycle Proteins metabolism
Lung pathology
MicroRNAs genetics
Biomarkers
Middle Aged
Scleroderma, Systemic genetics
Scleroderma, Systemic pathology
RNA, Circular genetics
Pulmonary Fibrosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 139
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 39053227
- Full Text :
- https://doi.org/10.1016/j.intimp.2024.112690