Association between Lp(a) and T2D: a Mendelian randomization study.

Authors :: Goławski M
Lejawa M
Banach M
Jóźwiak J
Gierlotka M
Osadnik T
Source :: Archives of medical science : AMS [Arch Med Sci] 2024 Apr 20; Vol. 20 (3), pp. 1002-1005. Date of Electronic Publication: 2024 Apr 20 (Print Publication: 2024).
Publication Year :: 2024
Abstract: Introduction: Blood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed. Methods: A two-sample MR analysis was conducted. Data were obtained from UK Biobank and FinnGen consortia. Primary analysis was based on an inverse-variance-weighted mean (IVM) approach. Results: No statistically significant association between the genetically predicted levels of Lp(a) and T2D was detected ( p = 0.362) in IVM analysis involving data of 563,420 patients. Conclusions: Genetically predicted Lp(a) concentration does not appear to be causally related to the risk of T2D. Competing Interests: The authors declare no conflict of interest in relation to the results of this analysis. (Copyright: © 2024 Termedia & Banach.)