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Leptin is a potential biomarker of childhood obesity and an indicator of the effectiveness of weight-loss interventions.

Authors :
Al Zein M
Akomolafe AF
Mahmood FR
Khrayzat A
Sahebkar A
Pintus G
Kobeissy F
Eid AH
Source :
Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2024 Nov; Vol. 25 (11), pp. e13807. Date of Electronic Publication: 2024 Jul 23.
Publication Year :
2024

Abstract

Childhood obesity represents a significant public health concern, imposing a substantial burden on the healthcare system. Furthermore, weight-loss programs often exhibit reduced effectiveness in adults who have a history of childhood obesity. Therefore, early intervention against childhood obesity is imperative. Presently, the primary method for diagnosing childhood obesity relies on body mass index (BMI), yet this approach has inherent limitations. Leptin, a satiety hormone produced by adipocytes, holds promise as a superior tool for predicting both childhood and subsequent adulthood obesity. In this review, we elucidate the tools employed for assessing obesity in children, delve into the biological functions of leptin, and examine the factors governing its expression. Additionally, we discuss maternal and infantile leptin levels as predictors of childhood obesity. By exploring the relationship between leptin levels and weight loss, we present leptin as a potential indicator of the effectiveness of obesity interventions.<br /> (© 2024 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.)

Details

Language :
English
ISSN :
1467-789X
Volume :
25
Issue :
11
Database :
MEDLINE
Journal :
Obesity reviews : an official journal of the International Association for the Study of Obesity
Publication Type :
Academic Journal
Accession number :
39044542
Full Text :
https://doi.org/10.1111/obr.13807