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Phylogeographic Analysis of Mycobacterium kansasii Isolates from Patients with M. kansasii Lung Disease in Industrialized City, Taiwan.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2024 Aug; Vol. 30 (8), pp. 1562-1570. - Publication Year :
- 2024
-
Abstract
- Little is known about environmental transmission of Mycobacterium kansasii. We retrospectively investigated potential environmental acquisition, primarily water sources, of M. kansasii among 216 patients with pulmonary disease from an industrial city in Taiwan during 2015-2017. We analyzed sputum mycobacterial cultures using whole-genome sequencing and used hierarchical Bayesian spatial network methods to evaluate risk factors for genetic relatedness of M. kansasii strains. The mean age of participants was 67 years; 24.1% had previously had tuberculosis. We found that persons from districts served by 2 water purification plants were at higher risk of being infected with genetically related M. kansasii isolates. The adjusted odds ratios were 1.81 (1.25-2.60) for the Weng Park plant and 1.39 (1.12-1.71) for the Fongshan plant. Those findings unveiled the association between water purification plants and M. kansasii pulmonary disease, highlighting the need for further environmental investigations to evaluate the risk for M. kansasii transmission.
- Subjects :
- Humans
Taiwan epidemiology
Aged
Male
Female
Middle Aged
Lung Diseases microbiology
Lung Diseases epidemiology
Phylogeny
Retrospective Studies
Aged, 80 and over
Risk Factors
Whole Genome Sequencing
Mycobacterium kansasii genetics
Mycobacterium kansasii isolation & purification
Mycobacterium Infections, Nontuberculous microbiology
Mycobacterium Infections, Nontuberculous epidemiology
Phylogeography
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 30
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 39043390
- Full Text :
- https://doi.org/10.3201/eid3008.240021