Examining the association of familial and social stress, trauma, and support on mood, anxiety, and behavioral symptoms and diagnoses in youth at risk for bipolar disorder and controls.

Introduction: Youth with a family history of bipolar disorder (At-Risk) have a higher risk of developing psychiatric disorders and experiencing environmental stressors than youth without such family history (Control). We studied the differential associations of familial and environmental factors on developing psychiatric diagnoses and symptoms, in At-Risk and Control youth.
Methods: At-Risk and Control youth (N = 466, ages 9-22) were systematically assessed for severity of symptoms, psychiatric diagnoses, and self-reported measures of stress and social support. We tested the association of family history and measures of stress or support with symptom severity and diagnoses.
Results: At-Risk youth had higher symptom severity scores and were more frequently diagnosed with psychiatric disorders (all p values < 0.001). When predicting mood symptom severity, family history had an interaction effect with stressful life events (p < 0.001) and number of distinct traumatic events (p = 0.001). In multivariate models, At-Risk status predicted anxiety disorders (OR = 2.7, CI 1.3-5.4, p = 0.005) and anxiety severity (Coefficient = 0.4, CI 0.2-0.7, p < 0.001) but not mood or behavioral disorder diagnoses or severity.
Limitations: Measures of stress and social support were based on self-report. Not all participants had passed through the period of risk for developing the outcomes under study and the follow up period was variable. We could not fully study the differential impact of physical or sexual abuse due to low frequency of occurrence in controls.
Conclusion: At-Risk youth exhibit more severe mood symptoms compared to Controls when exposed to similar levels of stress or trauma. At-Risk youth are also more prone to develop anxiety which may be a precursor for bipolar disorder.
Competing Interests: Declaration of competing interest Masoud Kamali has nothing to disclose. Emma K. Stapp has nothing to disclose. Janice M. Fullerton has received honoraria from Illumina for contribution to a Speakers Bureau in 2023 and had flight and accommodations paid for by Novo Nordisk Fonden to attend the Familial High Risk Summit. Neera Ghaziuddin has nothing to disclose. Leslie Hulvershorn has nothing to disclose. Melvin G. McInnis has received research support from Janssen Pharmaceuticals. Philip B. Mitchell has received remuneration from Janssen (Australia) for lectures and advisory board membership in the last 3 years. Gloria Roberts has nothing to disclose. Holly C. Wilcox has nothing to disclose. John I. Nurnberger Jr. has nothing to disclose.
(Copyright © 2024 Elsevier B.V. All rights reserved.)