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Magnetic molecularly imprinted polymer based on coordination for the determination of trace banned substance furosemide in human urine.
- Source :
-
Journal of separation science [J Sep Sci] 2024 Jul; Vol. 47 (14), pp. e2400003. - Publication Year :
- 2024
-
Abstract
- Furosemide (FUR), banned in sports events by the World Anti-Doping Agency, is a key target in drug tests, necessitating a pretreatment material capable of selectively, rapidly, and sufficiently separating/enriching analytes from complex matrices. Herein, a metal-mediated magnetic molecularly imprinted polymer (mMIP) was rationally designed and synthesized for the specific capture of FUR. The preparations involved the utilization of chromium (III) as the binding pivot, (3-aminopropyl)triethoxysilane as functional monomer, and Fe <subscript>3</subscript> O <subscript>4</subscript> as core, all assembled via free radical polymerization. Both the morphologies and adsorptive properties of the mMIP were characterized using multiple methods. The resulting Cr(III)-mediated mMIP (ChM-mMIP) presented excellent selectivity and specificity toward FUR. Under optimized conditions, the adsorption capacity reached 128.50 mg/g within 10 min, and the imprinting factor was 10.41. Moreover, it was also successfully applied as a dispersive solid-phase extraction material, enabling the detection of FUR concentration as low as 20 ng/mL in human urine samples when coupled with a high-performance liquid chromatography/photodiode array. Overall, this study offers a valuable strategy for the development of novel recognition material.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Humans
Adsorption
Molecular Imprinting
Solid Phase Extraction
Surface Properties
Chromatography, High Pressure Liquid
Particle Size
Doping in Sports prevention & control
Polymers chemistry
Polymers chemical synthesis
Furosemide urine
Furosemide chemistry
Molecularly Imprinted Polymers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1615-9314
- Volume :
- 47
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Journal of separation science
- Publication Type :
- Academic Journal
- Accession number :
- 39034895
- Full Text :
- https://doi.org/10.1002/jssc.202400003