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ADATs: roles in tRNA editing and relevance to disease.

ADATs: roles in tRNA editing and relevance to disease.

Authors :
Mao XL
Eriani G
Zhou XL
Source :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2024 Jul 22. Date of Electronic Publication: 2024 Jul 22.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Transfer RNAs (tRNAs) play central roles in protein biosynthesis. Post-transcriptional RNA modifications affect tRNA function and stability. Among these modifications, RNA editing is a widespread RNA modification in three domains of life. Proteins of the adenosine deaminase acting on tRNA (ADAT) family were discovered more than 20 years ago. They catalyze the deamination of adenosine to inosine (A-to-I) or cytidine to uridine (C-to-U) during tRNA maturation. The most studied example is the TadA- or ADAT2/3-mediated A-to-I conversion of the tRNA wobble position in the anticodon of prokaryotic or eukaryotic tRNAs, respectively. This review provides detailed information on A-to-I and C-to-U editing of tRNAs in different domains of life, presents recent new findings on ADATs for DNA editing, and finally comments on the association of mutations in the ADAT3 gene with intellectual disability.

Details

Language :
English
ISSN :
1745-7270
Database :
MEDLINE
Journal :
Acta biochimica et biophysica Sinica
Publication Type :
Academic Journal
Accession number :
39034823
Full Text :
https://doi.org/10.3724/abbs.2024125