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GLYCOCINS: The sugar peppered antimicrobials.
- Source :
-
Biotechnology advances [Biotechnol Adv] 2024 Oct; Vol. 75, pp. 108415. Date of Electronic Publication: 2024 Jul 19. - Publication Year :
- 2024
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Abstract
- Glycosylated bacteriocins, known as glycocins, were first discovered in 2011. These bioactive peptides are produced by bacteria to gain survival advantages. They exhibit diverse types of glycans and demonstrate varied antimicrobial activity. Currently, there are 13 experimentally known glycocins, with over 250 identified in silico across different bacterial phyla. Notably, glycocins are recognized for their glycan-mediated antimicrobial activity, proving effective against drug-resistant and foodborne pathogens. Many glycocins contain rare S-linked glycans. Glycosyltransferases (GTs), responsible for transferring sugar to glycocins and involved in glycocin biosynthesis, often cluster together in the producer's genome. This clustering makes them valuable for custom glycoengineering with diverse substrate specificities. Heterologous expression of glycocins has paved the way for the establishment of microbial factories for glycopeptide and glycoconjugate production across various industries. In this review, we emphasize the primary roles of fully and partially characterized glycocins and their glycosylating enzymes. Additionally, we explore how specific glycan structures facilitate these functions in antibacterial activities. Furthermore, we discuss newer approaches and increasing efforts aimed at exploiting bacterial glycobiology for the development of food preservatives and as replacements or complements to traditional antibiotics, particularly in the face of antibiotic-resistant pathogenic bacteria.<br />Competing Interests: Declaration of competing interest There are no conflicts to declare.<br /> (Copyright © 2024. Published by Elsevier Inc.)
- Subjects :
- Polysaccharides chemistry
Polysaccharides metabolism
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents metabolism
Bacteria drug effects
Bacteria metabolism
Glycosylation
Bacteriocins chemistry
Bacteriocins metabolism
Bacteriocins pharmacology
Bacteriocins genetics
Anti-Infective Agents pharmacology
Anti-Infective Agents metabolism
Anti-Infective Agents chemistry
Glycosyltransferases metabolism
Glycosyltransferases genetics
Glycosyltransferases chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1899
- Volume :
- 75
- Database :
- MEDLINE
- Journal :
- Biotechnology advances
- Publication Type :
- Academic Journal
- Accession number :
- 39033836
- Full Text :
- https://doi.org/10.1016/j.biotechadv.2024.108415