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Structural and optical properties of alginate-based antibacterial dressing with calcium phosphate and zinc oxide for biodegradable wound painting applications.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2024 Sep; Vol. 276 (Pt 2), pp. 133996. Date of Electronic Publication: 2024 Jul 18. - Publication Year :
- 2024
-
Abstract
- The skin is the outermost part of the body. Although susceptible to damage, the skin is in direct contact with the external environment. Wound dressing is a clinical method that plays a vital role in wound healing. Herein, we developed an antibacterial wound dressing using alginate as the basic material. The dressing was prepared using the solvent casting method, which was used to analyze the effects of adding CaP and ZnO on its structural, optical, and antibacterial properties. Adding CaP exhibited strong but stiff mechanical properties, unlike the CaP/ZnO, which possessed high strength and elasticity. The optical properties of sample S2 did not have a considerable impact. By contrast, the addition of ZnO to sample S3 notably increases the wavelength and absorption value. The diameter of the inhibition zone for S. aureus bacteria exhibited a successive increase in its antibacterial properties, and sample S3 exhibited the highest value. Thus, sample S3 is the most promising wound dressing concerning speeding up the wound healing process because it possesses the most optimal mechanical, optical, and antibacterial properties. The main limitation to be addressed is that sample S3 cannot be easily digested in the environment.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Microbial Sensitivity Tests
Humans
Optical Phenomena
Zinc Oxide chemistry
Zinc Oxide pharmacology
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Alginates chemistry
Alginates pharmacology
Bandages
Staphylococcus aureus drug effects
Wound Healing drug effects
Calcium Phosphates chemistry
Calcium Phosphates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 276
- Issue :
- Pt 2
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 39032876
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.133996