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Modulation of gene expression in skin wound healing by photobiomodulation therapy: A systematic review in vivo studies.
- Source :
-
Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2024 Jul; Vol. 40 (4), pp. e12990. - Publication Year :
- 2024
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Abstract
- Background: Wound healing is a multistep process involving coordinated responses of a variety of cell types, cytokines, growth factors, and extracellular matrix (ECM) components leading to the physiological restoration of tissue integrity. Photobiomodulation therapy (PBMT) has been highlighted as an approach to improve the healing process, nonetheless at the molecular level, the effects of PBMT are not entirely understood.<br />Aim: To systematically review publications that investigated gene expression after PBMT during in vivo skin repair.<br />Methods: An electronic search was undertaken in Medline Ovid (Wolters Kluwer), PubMed (National Library of Medicine), Web of Science (Thomson Reuters), Scopus (Elsevier), Embase, and LILACS databases. The search strategy was conducted from the terms: low-level light therapy, gene expression, and wound healing and their synonyms. The databases were consulted in December 2023 and no publication year limit was used.<br />Results: Eleven studies were included in this review and the expression of 186 genes was evaluated. PBMT modified the expression of several targets genes studied, such as down-regulation of genes related to extracellular matrix proteases (MMP2 and MMP9) and pro-inflammatory cytokines (IL10 and IL6) and up-regulation of DNMT3A and BFGF.<br />Conclusion: This review demonstrates that PBMT is capable of regulating gene expression during wound healing. Most evidence showed a positive impact of PBMT in regulating genes linked to inflammatory cytokines improving skin wound healing. Yet, the effects of PBMT in genes involved in other mechanisms still need to be better understood.<br /> (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Animals
Humans
Cytokines metabolism
Gene Expression radiation effects
Gene Expression Regulation radiation effects
Matrix Metalloproteinase 2 metabolism
Matrix Metalloproteinase 2 genetics
Matrix Metalloproteinase 9 metabolism
Matrix Metalloproteinase 9 genetics
Low-Level Light Therapy
Skin metabolism
Skin radiation effects
Skin pathology
Skin injuries
Wound Healing radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0781
- Volume :
- 40
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Photodermatology, photoimmunology & photomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 39031566
- Full Text :
- https://doi.org/10.1111/phpp.12990