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Genetic Polymorphisms in Cardiovascular Disease: Effects Across Three Generations Exposed to Radiation from the Semipalatinsk Nuclear Test Site.
- Source :
-
Cardiovascular toxicology [Cardiovasc Toxicol] 2024 Sep; Vol. 24 (9), pp. 870-878. Date of Electronic Publication: 2024 Jul 19. - Publication Year :
- 2024
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Abstract
- The population in the areas neighboring the Semipalatinsk Nuclear Test Site (SNTS) in the eastern region of Kazakhstan faces increased cardiovascular disease (CVD) risk. Previous research has not explored gene polymorphisms related to CVD in this population. Therefore, the present study examines the prevalence of six CVD-associated genotypes in three generations exposed to SNTS radiation. The genotyping of ApoE Leu28 → Pro, AGT Met174 → Thr, AGT Met235 → Thr, eNOS T786 → C, PON1 Gln192 → Arg, and EDN 1 Lys198 → Asn was performed using real-time polymerase chain reaction. The present study encompassed a cohort of 218 participants with a familial history of arterial hypertension and/or carotid artery disease spanning at least three generations. The analysis unveiled significant disparities in the prevalence of ApoE Leu28 → Pro, eNOS T786 → C, and PON1 Gln192 → Arg genotypes across different generations. Furthermore, a substantial variation in the distribution of the eNOS T786 → C genotype was observed between individuals of Kazakh and Russian ethnicities. Nevertheless, no significant discrepancies were detected in the frequencies of the investigated genotypes between genders. Further research in this area is warranted to enhance the understanding of the genetic factors contributing to CVD in the population exposed to radiation from the SNTS. Specifically, future studies should broaden the scope of genetic polymorphisms investigated and include representatives of healthy individuals who have not been exposed to radiation as controls.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Male
Female
Kazakhstan epidemiology
Middle Aged
Adult
Aryldialkylphosphatase genetics
Nuclear Weapons
Phenotype
Apolipoproteins E genetics
Risk Assessment
Heredity
Gene Frequency
Pedigree
Cardiovascular Diseases genetics
Cardiovascular Diseases epidemiology
Cardiovascular Diseases diagnosis
Heart Disease Risk Factors
Aged
Risk Factors
Gene-Environment Interaction
Prevalence
Carotid Artery Diseases genetics
Carotid Artery Diseases epidemiology
Genetic Predisposition to Disease
Nitric Oxide Synthase Type III genetics
Polymorphism, Genetic
Radiation Exposure adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0259
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cardiovascular toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 39030318
- Full Text :
- https://doi.org/10.1007/s12012-024-09885-y