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Preconditioning by Moderate-Intensity Exercise Prevents Gentamicin-Induced Acute Kidney Injury.
- Source :
-
International journal of sports medicine [Int J Sports Med] 2024 Jul 19. Date of Electronic Publication: 2024 Jul 19. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- A strict correlation among proximal tubule epithelial cell dysfunction, proteinuria, and modulation of the Renin-Angiotensin System and Kalikrein-Kinin System are crucial factors in the pathogenesis of Acute Kidney Injury (AKI). In this study, we investigated the potential protective effect of preconditioning by moderate-intensity aerobic exercise on gentamicin-induced AKI. Male Wistar rats were submitted to a moderate-intensity treadmill exercise protocol for 8 weeks, and then injected with 80 mg/kg/day s.c. gentamicin for 5 consecutive days. Four groups were generated: 1) NT+SAL (control); 2) NT+AKI (non-trained with AKI); 3) T+SAL (trained); and 4) T+AKI (trained with AKI). The NT+AKI group presented: 1) impairment in glomerular function parameters; 2) increased fractional excretion of Na <superscript>+</superscript> , K <superscript>+</superscript> , and water; 4) proteinuria and increased urinary γ-glutamyl transferase activity (a marker of tubular injury) accompanied by acute tubular necrosis; 5) an increased renal angiotensin-converting enzyme and bradykinin B1 receptor mRNA expression. Interestingly, the preconditioning by moderate-intensity aerobic exercise attenuated all alterations observed in gentamicin-induced AKI (T+AKI group). Taken together, our results show that the preconditioning by moderate-intensity aerobic exercise ameliorates the development of gentamicin-induced AKI. Our findings help to expand the current knowledge regarding the effect of physical exercise on kidneys during physiological and pathological conditions.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Thieme. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1439-3964
- Database :
- MEDLINE
- Journal :
- International journal of sports medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39029513
- Full Text :
- https://doi.org/10.1055/a-2342-2154