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Transcription factor dependencies identify BAF-dependent cancers.
- Source :
-
Cancer cell [Cancer Cell] 2024 Aug 12; Vol. 42 (8), pp. 1326-1328. Date of Electronic Publication: 2024 Jul 18. - Publication Year :
- 2024
-
Abstract
- In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple myeloma and POU2F3-subtype small cell lung cancer, highlighting potential therapeutic applications for BAF complex inhibitors/degraders.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Chromatin Assembly and Disassembly
Interferon Regulatory Factors metabolism
Interferon Regulatory Factors genetics
Multiple Myeloma genetics
Multiple Myeloma metabolism
Multiple Myeloma pathology
Neoplasms genetics
Neoplasms metabolism
DNA-Binding Proteins metabolism
DNA-Binding Proteins genetics
Lung Neoplasms genetics
Lung Neoplasms metabolism
Lung Neoplasms pathology
Small Cell Lung Carcinoma genetics
Small Cell Lung Carcinoma metabolism
Small Cell Lung Carcinoma pathology
Transcription Factors metabolism
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 42
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 39029465
- Full Text :
- https://doi.org/10.1016/j.ccell.2024.06.013