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Identification of Sarmentosin as a Key Bioactive from Blackcurrants ( Ribes nigrum ) for Inhibiting Platelet Monoamine Oxidase in Humans.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jul 31; Vol. 72 (30), pp. 16777-16789. Date of Electronic Publication: 2024 Jul 19. - Publication Year :
- 2024
-
Abstract
- Previous clinical studies indicate that monoamine oxidase-B (MAO-B) inhibition by blackcurrants must be predominantly attributed to bioactives other than anthocyanins. In this natural products discovery study, MAO-A/B inhibitory phytochemicals were isolated from blackcurrants, and a double-blind crossover study investigated the efficacy of freeze-dried whole-fruit blackcurrant powder in inhibiting MAO-B compared with blackcurrant juice in healthy adults. Platelet MAO-B inhibition was comparable between powder (89% ± 6) and juice (91% ± 4), and it was positively correlated with MAO-modulated plasma catecholamines, subjective alertness, and reduced mental fatigue, assessed using the Bond-Lader questionnaire. Sarmentosin, a nitrile glycoside, and its hydroxycinnamoyl esters were identified as novel MAO-A/B inhibitors from blackcurrant in vitro , and sarmentosin was demonstrated to inhibit platelet MAO-B activity in vivo . These findings confirm sarmentosin as the primary bioactive for MAO-A/B inhibition in blackcurrants, as well as its bioavailability and stability during freeze-drying, and suggest that consuming blackcurrant powder and juice may positively affect mood in healthy adults.
- Subjects :
- Humans
Adult
Male
Female
Young Adult
Double-Blind Method
Fruit chemistry
Middle Aged
Ribes chemistry
Monoamine Oxidase metabolism
Monoamine Oxidase Inhibitors pharmacology
Monoamine Oxidase Inhibitors chemistry
Plant Extracts chemistry
Plant Extracts pharmacology
Blood Platelets drug effects
Blood Platelets enzymology
Blood Platelets metabolism
Cross-Over Studies
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 72
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 39028868
- Full Text :
- https://doi.org/10.1021/acs.jafc.4c03802