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Cocoa extract induces browning of white adipocytes and improves glucose intolerance in mice fed a high-fat diet.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2024 Sep 20; Vol. 88 (10), pp. 1188-1198. - Publication Year :
- 2024
-
Abstract
- Cocoa extract (CE) offers several health benefits, such as antiobesity and improved glucose intolerance. However, the mechanisms remain unclear. Adipose tissue includes white adipose tissue (WAT) and brown adipose tissue. Brown adipose tissue leads to body fat reduction by metabolizing lipids to heat via uncoupling protein 1 (UCP1). The conversion of white adipocytes into brown-like adipocytes (beige adipocytes) is called browning, and it contributes to the anti-obesity effect and improved glucose tolerance. This study aimed to evaluate the effect of CE on glucose tolerance in terms of browning. We found that dietary supplementation with CE improved glucose intolerance in mice fed a high-fat diet, and it increased the expression levels of Ucp1 and browning-associated gene in inguinal WAT. Furthermore, in primary adipocytes of mice, CE induced Ucp1 expression through β3-adrenergic receptor stimulation. These results suggest that dietary CE improves glucose intolerance by inducing browning in WAT.<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
- Subjects :
- Animals
Mice
Male
Adipose Tissue, White drug effects
Adipose Tissue, White metabolism
Receptors, Adrenergic, beta-3 metabolism
Receptors, Adrenergic, beta-3 genetics
Adipose Tissue, Brown drug effects
Adipose Tissue, Brown metabolism
Adipocytes, Brown drug effects
Adipocytes, Brown metabolism
Diet, High-Fat adverse effects
Glucose Intolerance drug therapy
Glucose Intolerance metabolism
Cacao chemistry
Plant Extracts pharmacology
Uncoupling Protein 1 metabolism
Uncoupling Protein 1 genetics
Adipocytes, White drug effects
Adipocytes, White metabolism
Mice, Inbred C57BL
Subjects
Details
- Language :
- English
- ISSN :
- 1347-6947
- Volume :
- 88
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 39025807
- Full Text :
- https://doi.org/10.1093/bbb/zbae105