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Chromogranin: a newly recognized marker for endocrine cells of the human gastrointestinal tract.
- Source :
-
Gastroenterology [Gastroenterology] 1985 Dec; Vol. 89 (6), pp. 1366-73. - Publication Year :
- 1985
-
Abstract
- Existing methods for the histochemical demonstration of gastrointestinal cells are somewhat limited. Chromogranin represents a family of proteins that coexist with catecholamines in the secretory vesicles of adrenal medulla cells. In the present study, immunocytochemistry was used to test whether chromogranin is a marker for gut endocrine cells. Serial sections of each area of human gut were immunostained for chromogranin and for the amine and each of the peptides known to be present in mucosal endocrine cells. Chromogranin was immunostained in large numbers of endocrine cells in all tissues examined. All identified endocrine cell types were found, in serial sections or by sequential silver impregnations, to be chromogranin immunoreactive. However, the possibility exists that some chromogranin-immunoreactive cells contain a yet to be discovered endocrine substance. Immunostaining of chromogranin thus appears to provide a means for demonstrating all gastrointestinal mucosal endocrine cells identifiable by the methods described in this study.
- Subjects :
- Digestive System analysis
Enterochromaffin Cells analysis
Gastric Inhibitory Polypeptide analysis
Gastric Mucosa analysis
Gastric Mucosa cytology
Gastrins analysis
Histocytochemistry
Humans
Immunoenzyme Techniques
Intestinal Mucosa analysis
Intestinal Mucosa cytology
Neurotensin analysis
Secretin analysis
Serotonin analysis
Chromogranins analysis
Digestive System cytology
Nerve Tissue Proteins analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0016-5085
- Volume :
- 89
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 3902554
- Full Text :
- https://doi.org/10.1016/0016-5085(85)90657-2