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Multiple antimicrobial and immune-modulating activities of cysteamine in infectious diseases.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Sep; Vol. 178, pp. 117153. Date of Electronic Publication: 2024 Jul 17. - Publication Year :
- 2024
-
Abstract
- Infectious diseases are a major threat to global health and cause millions of deaths every year, particularly in developing countries. The emergence of multidrug resistance challenges current antimicrobial treatments, inducing uncertainty in therapeutic protocols. New compounds are therefore necessary. A drug repurposing approach could play a critical role in developing new treatments used either alone or in combination with standard therapy regimens. Herein, we focused on cysteamine, an aminothiol endogenously synthesized by human cells during the degradation of coenzyme-A, which is a drug approved for the treatment of nephropathic cystinosis. Cysteamine influences many biological processes due to the presence of the highly reactive thiol group. This review provides an overview of cysteamine-mediated effects on different viruses, bacteria and parasites, with a particular focus on infections caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Mycobacterium tuberculosis, non-tuberculous mycobacteria (NTM), and Pseudomonas aeruginosa. Evidences for a potential use of cysteamine as a direct antimicrobial agent and/or a host-directed therapy, either alone or in combination with other antimicrobial drugs, are described.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.The authors declare no competing interests.<br /> (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Humans
Animals
Communicable Diseases drug therapy
Communicable Diseases microbiology
Drug Repositioning
Immunomodulating Agents pharmacology
Immunomodulating Agents therapeutic use
COVID-19
COVID-19 Drug Treatment
SARS-CoV-2 drug effects
Cysteamine pharmacology
Cysteamine therapeutic use
Anti-Infective Agents pharmacology
Anti-Infective Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 178
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 39024833
- Full Text :
- https://doi.org/10.1016/j.biopha.2024.117153