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QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism.

Authors :
Hosomi K
Hatanaka N
Hinenoya A
Adachi J
Tojima Y
Furuta M
Uchiyama K
Morita M
Nagatake T
Saika A
Kawai S
Yoshii K
Kondo S
Yamasaki S
Kunisawa J
Source :
Frontiers in microbiology [Front Microbiol] 2024 Jul 02; Vol. 15, pp. 1415893. Date of Electronic Publication: 2024 Jul 02 (Print Publication: 2024).
Publication Year :
2024

Abstract

Introduction: Campylobacter spp. are a public health concern, yet there is still no effective vaccine or medicine available.<br />Methods: Here, we developed a Campylobacter jejuni -specific antibody and found that it targeted a menaquinol cytochrome c reductase complex QcrC.<br />Results: The antibody was specifically reactive to multiple C. jejuni strains including clinical isolates from patients with acute enteritis and was found to inhibit the energy metabolism and growth of C. jejuni . Different culture conditions produced different expression levels of QcrC in C. jejuni , and these levels were closely related not only to the energy metabolism of C. jejuni but also its pathogenicity. Furthermore, immunization of mice with recombinant QcrC induced protective immunity against C. jejuni infection.<br />Discussion: Taken together, our present findings highlight a possible antibody- or vaccination-based strategy to prevent or control Campylobacter infection by targeting the QcrC-mediated metabolic pathway.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Hosomi, Hatanaka, Hinenoya, Adachi, Tojima, Furuta, Uchiyama, Morita, Nagatake, Saika, Kawai, Yoshii, Kondo, Yamasaki and Kunisawa.)

Details

Language :
English
ISSN :
1664-302X
Volume :
15
Database :
MEDLINE
Journal :
Frontiers in microbiology
Publication Type :
Academic Journal
Accession number :
39015740
Full Text :
https://doi.org/10.3389/fmicb.2024.1415893