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Blood eosinophilia and a higher ethmoid sinus/maxillary sinus score ratio predict new-onset asthma in patients with chronic rhinosinusitis with nasal polyps.
- Source :
-
Acta oto-laryngologica [Acta Otolaryngol] 2024 Apr; Vol. 144 (4), pp. 313-319. Date of Electronic Publication: 2024 Jul 16. - Publication Year :
- 2024
-
Abstract
- Backgroud: Presently, the impact of Chronic rhinosinusitis with nasal polyps (CRSwNP) on asthma onset is unknown.<br />Aims: To evaluate the role of CRSwNP in asthma onset.<br />Materials and Methods: A total of 3107 CRSwNP patients were retrospectively screened from 1 January 2018, to 31 May 2021; 624 patients were enrolled. Clinical data regarding nasal symptoms, Lund-Mackay scores, blood eosinophil percentage, and onset of asthma were analyzed. Patients were divided into different groups according to past history of nasal polyps, Lund-Mackay score, and the extent of blood eosinophilia. Asthma-free rates between these subgroups were analyzed by Kaplan-Meier curves and Cox regression models.<br />Results: The prevalence of asthma was 10.90% in patients with CRSwNP, and new-onset asthma occurred in 3.14% of these patients. Higher Lund-Mackay scores for ethmoid sinus and maxillary sinus (E/M) and blood eosinophil percentages were two independent risk factors for new-onset asthma, with hazard ratios of 1.267 (95%CI, 1.155-1.390) and 1.224 (95%CI, 1.054-1.422), respectively. CRSwNP patients with an E/M ratio > 2.33 or a blood Eos percentage > 5.5% were at risk for asthma onset.<br />Conclusions and Significance: Blood eosinophilia and a higher E/M score ratio were associated with new-onset asthma in patients with CRSwNP.
- Subjects :
- Humans
Male
Female
Middle Aged
Chronic Disease
Retrospective Studies
Adult
Maxillary Sinus
Risk Factors
Prevalence
Aged
Rhinosinusitis
Sinusitis complications
Sinusitis blood
Asthma complications
Asthma epidemiology
Nasal Polyps complications
Nasal Polyps blood
Nasal Polyps epidemiology
Rhinitis complications
Rhinitis blood
Eosinophilia complications
Eosinophilia blood
Eosinophilia epidemiology
Ethmoid Sinus
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2251
- Volume :
- 144
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta oto-laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 39011988
- Full Text :
- https://doi.org/10.1080/00016489.2024.2362776