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Trends in analgesia-sedation of pediatric patients receiving I-131 MIBG in the pediatric intensive care unit: A report from the Pediatric Health Information System database.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2024 Oct; Vol. 71 (10), pp. e31205. Date of Electronic Publication: 2024 Jul 15. - Publication Year :
- 2024
-
Abstract
- Background: Children with neuroblastoma receiving I-131 metaiodobenzylguanidine (MIBG) therapy require sedation-analgesia for strict radiation safety precautions during MIBG infusion and clearance. We evaluated the sedation-analgesia trends of patients undergoing MIBG therapy using the Pediatric Health Information System (PHIS) database.<br />Materials and Methods: Retrospective data from 476 patient encounters from the PHIS from 2010 to 2019.<br />Results: Total 240/476 (50.45%) children evaluated were under 6 years of age. Compared to 2010, in 2018 there was a decrease in benzodiazepine infusion use (60% vs. 40%, p < .04), as well as a decrease in use of opiate infusion (35% vs. 25%, p < .001). Compared to 2010, in 2018 we report an increase in the use of ketamine (from 5% to 10%, p < .002), as well as an increase in dexmedetomidine use (0% vs. 30%, p < .001). Dexmedetomidine was the most used medication in the 0-3 years age group compared to children older than 3 years of age (14.19% vs. 5.80%, p < .001). Opiate was the most used medication in children greater than 3 years compared to the 0-3-year age group (36.23 vs. 23.87, p < .05).<br />Conclusion: Using PHIS data, we discovered considerable variability in the medications used for sedation in patients undergoing MIBG therapy. Although benzodiazepines and opioids were the most used agents, there was a trend toward decreasing use of benzodiazepines and opioids in these patients. Furthermore, there has been an increasing trend in the use of dexmedetomidine and ketamine.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Humans
Child, Preschool
Infant
Child
Male
Female
Retrospective Studies
Adolescent
Infant, Newborn
Analgesia methods
Analgesia statistics & numerical data
Iodine Radioisotopes therapeutic use
Iodine Radioisotopes administration & dosage
Hypnotics and Sedatives administration & dosage
Hypnotics and Sedatives therapeutic use
Follow-Up Studies
Prognosis
Radiopharmaceuticals therapeutic use
Radiopharmaceuticals administration & dosage
Databases, Factual
Neuroblastoma radiotherapy
3-Iodobenzylguanidine therapeutic use
3-Iodobenzylguanidine administration & dosage
Intensive Care Units, Pediatric
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 71
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 39010648
- Full Text :
- https://doi.org/10.1002/pbc.31205