Back to Search
Start Over
Beta activity in human anterior cingulate cortex mediates reward biases.
- Source :
-
Nature communications [Nat Commun] 2024 Jul 15; Vol. 15 (1), pp. 5528. Date of Electronic Publication: 2024 Jul 15. - Publication Year :
- 2024
-
Abstract
- The rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is implemented in the brain is important for many reasons, including the fact that diminution in reward biasing is a hallmark of clinical depression. We hypothesized that reward biasing is mediated by the anterior cingulate cortex (ACC), a cortical hub region associated with the integration of reward and executive control and with the etiology of depression. To test this hypothesis, we recorded neural activity during a biased judgment task in patients undergoing intracranial monitoring for either epilepsy or major depressive disorder. We found that beta (12-30 Hz) oscillations in the ACC predicted both associated reward and the size of the choice bias, and also tracked reward receipt, thereby predicting bias on future trials. We found reduced magnitude of bias in depressed patients, in whom the beta-specific effects were correspondingly reduced. Our findings suggest that ACC beta oscillations may orchestrate the learning of reward information to guide adaptive choice, and, more broadly, suggest a potential biomarker for anhedonia and point to future development of interventions to enhance reward impact for therapeutic benefit.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Adult
Female
Choice Behavior physiology
Middle Aged
Beta Rhythm physiology
Epilepsy physiopathology
Young Adult
Reward
Gyrus Cinguli physiology
Gyrus Cinguli diagnostic imaging
Gyrus Cinguli physiopathology
Depressive Disorder, Major physiopathology
Depressive Disorder, Major psychology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 39009561
- Full Text :
- https://doi.org/10.1038/s41467-024-49600-7