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Programming of in Situ Tumor Vaccines via Supramolecular Nanodrug/Hydrogel Composite and Deformable Nanoadjuvant for Cancer Immunotherapy.
- Source :
-
Nano letters [Nano Lett] 2024 Jul 24; Vol. 24 (29), pp. 9017-9026. Date of Electronic Publication: 2024 Jul 15. - Publication Year :
- 2024
-
Abstract
- The development of in situ tumor vaccines offers promising prospects for cancer treatment. Nonetheless, the generation of plenary autologous antigens in vivo and their codelivery to DC cells along with adjuvants remains a significant challenge. Herein, we developed an in situ tumor vaccine using a supramolecular nanoparticle/hydrogel composite (ANP <subscript>MTO</subscript> /ALCD) and a deformable nanoadjuvant (PPE <subscript>R848</subscript> ). The ANP <subscript>MTO</subscript> /ALCD composite consisted of β-cyclodextrin-decorated alginate (Alg- g -CD) and MTO-encapsulated adamantane-decorated nanoparticles (ANP <subscript>MTO</subscript> ) through supramolecular interaction, facilitating the long-term and sustained production of plenary autologous antigens, particularly under a 660 nm laser. Simultaneously, the produced autologous antigens were effectively captured by nanoadjuvant PPE <subscript>R848</subscript> and subsequently transported to lymph nodes and DC cells, benefiting from its optimized size and deformability. This in situ tumor vaccine can trigger a robust antitumor immune response and demonstrate significant therapeutic efficacy in inhibiting tumor growth, suppressing tumor metastasis, and preventing postoperative recurrence, offering a straightforward approach to programming in situ tumor vaccines.
- Subjects :
- Animals
Mice
Hydrogels chemistry
Humans
Cell Line, Tumor
Dendritic Cells immunology
beta-Cyclodextrins chemistry
Neoplasms therapy
Neoplasms immunology
Alginates chemistry
Adamantane chemistry
Adamantane therapeutic use
Cancer Vaccines chemistry
Cancer Vaccines administration & dosage
Cancer Vaccines immunology
Cancer Vaccines therapeutic use
Immunotherapy methods
Nanoparticles chemistry
Adjuvants, Immunologic chemistry
Adjuvants, Immunologic administration & dosage
Adjuvants, Immunologic therapeutic use
Adjuvants, Immunologic pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6992
- Volume :
- 24
- Issue :
- 29
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 39007530
- Full Text :
- https://doi.org/10.1021/acs.nanolett.4c02113