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Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long-term complications of inadequate immunosuppression.
- Source :
-
Journal of medical virology [J Med Virol] 2024 Jul; Vol. 96 (7), pp. e29806. - Publication Year :
- 2024
-
Abstract
- Optimization of individual immunosuppression, which reduces the risks of both graft loss and patients' death, is considered the best approach to improve long-term outcomes of renal transplantation. Torque Teno Virus (TTV) DNAemia has emerged as a potential biomarker reflecting the depth of therapeutic immunosuppression during the initial year post-transplantation. However, its efficacy in long-term monitoring remains uncertain. In a cohort study involving 34 stable kidney transplant recipients and 124 healthy volunteers, we established lower and upper TTV DNAemia thresholds (3.75-5.1 log10 cp/mL) correlating with T-cell activatability, antibody response against flu vaccine, and risk for subsequent serious infections or cancer over 50 months. Validation in an independent cohort of 92 recipients confirmed that maintaining TTV DNAemia within this range in >50% of follow-up time points was associated with reduced risks of complications due to inadequate immunosuppression, including de novo DSA, biopsy-proven antibody-mediated rejection, graft loss, infections, or cancer. Multivariate analysis highlighted "in-target" TTV DNAemia as the sole independent variable significantly linked to decreased risk for long-term complications due to inadequate immunosuppression (odds ratio [OR]: 0.27 [0.09-0.77]; p = 0.019). Our data suggest that the longitudinal monitoring of TTV DNAemia in kidney transplant recipients could help preventing the long-term complications due to inadequate immunosuppression.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Longitudinal Studies
Aged
Graft Rejection
Immunosuppressive Agents therapeutic use
Immunosuppressive Agents adverse effects
Cohort Studies
Viremia
Torque teno virus genetics
Kidney Transplantation adverse effects
DNA, Viral blood
Transplant Recipients
DNA Virus Infections virology
DNA Virus Infections blood
DNA Virus Infections immunology
Immunosuppression Therapy adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1096-9071
- Volume :
- 96
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of medical virology
- Publication Type :
- Academic Journal
- Accession number :
- 39007420
- Full Text :
- https://doi.org/10.1002/jmv.29806