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Efficacy of Rose Bengal-Mediated Antimicrobial Photodynamic Therapy as an Adjunct to Scaling and Root Planing on Clinical and Microbiological Parameters in the Management of Chronic Periodontitis: A Single-Blinded, Randomized Controlled Clinical Trial.
- Source :
-
Photobiomodulation, photomedicine, and laser surgery [Photobiomodul Photomed Laser Surg] 2024 Aug; Vol. 42 (8), pp. 561-567. Date of Electronic Publication: 2024 Jul 15. - Publication Year :
- 2024
-
Abstract
- Aim: The study aims to assess the efficacy of rose bengal (RB)-mediated antimicrobial photodynamic therapy (a-PDT) as an adjunct to scaling and root planing in the management of chronic periodontitis patients in terms of clinical parameters like gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and microbiological parameters like total microbial count, total red complex organism count, Porphyromonas gingivalis count, Treponema denticola count, and Tannerella forsythia count. Materials and Methods: In this randomized controlled clinical trial, a total of 30 patients were recruited who met the inclusion criteria. The participants were randomly allocated into group A with scaling and root planning (SRP) alone and group B with SRP + a-PDT. The clinical and microbiological parameters were measured at baseline and at 3-month follow-up. Intergroup and intragroup comparisons were performed using independent t test and paired t test, respectively. Value of p < 0.05 was considered as statistically significant. Results: At 3-month follow-up, group B treated with SRP + a-PDT showed statistically significant reduction in GI (0.58 ± 0.20) and PPD (1.81 ± 0.32 mm), gain in CAL (0.73 ± 0.04 mm), and reduction in total microbial count [2.80 ± 0.08 × 10 <superscript>4</superscript> colony forming unit (CFU)], total red complex count (0.29 ± 0.14 × 10 <superscript>2</superscript> CFU), P. gingivalis count (0.43 ± 0.13 × 10 <superscript>2</superscript> CFU), T. denticola count (0.61 ± 0.04 × 10 <superscript>2</superscript> CFU), and T. forsythia count (0.59 ± 0.04 × 10 <superscript>2</superscript> CFU) as compared with group A ( p < 0.05). Conclusion: RB-mediated a-PDT as an adjunct to SRP was significantly more effective in improving GI, PPD, and CAL and in reducing microbial count as compared with SRP alone in the management of chronic periodontitis.
- Subjects :
- Humans
Male
Female
Adult
Single-Blind Method
Middle Aged
Photosensitizing Agents therapeutic use
Combined Modality Therapy
Porphyromonas gingivalis
Periodontal Index
Treatment Outcome
Treponema denticola
Chronic Periodontitis therapy
Chronic Periodontitis microbiology
Chronic Periodontitis drug therapy
Photochemotherapy methods
Dental Scaling
Rose Bengal therapeutic use
Root Planing
Subjects
Details
- Language :
- English
- ISSN :
- 2578-5478
- Volume :
- 42
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Photobiomodulation, photomedicine, and laser surgery
- Publication Type :
- Academic Journal
- Accession number :
- 39007179
- Full Text :
- https://doi.org/10.1089/pho.2024.0037