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Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer.
- Source :
-
Oral diseases [Oral Dis] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Objective: To compare salivary flow rates between females and males, before and after radiation therapy (RT) for head and neck cancer (HNC).<br />Methods: Prospective observational multicenter cohort study (OraRad). Stimulated whole salivary flow was measured before RT and at 6 and 18 months after RT.<br />Results: Mean (95% confidence interval) salivary flow in g/min before RT was 0.81 (0.71, 0.90) in females (n = 107) and 1.20 (1.15, 1.25) in males (n = 391) (p < 0.001); at 6 months was 0.34 (0.24, 0.44) in females and 0.50 (0.44, 0.55) in males (p = 0.01); at 18 months was 0.49 (0.38, 0.59) in females and 0.70 (0.64, 0.75) in males (p < 0.001). Median nadir salivary flow after RT was 0.22 in females and 0.35 in males (p < 0.001). A lower nadir salivary flow in females, but not males, was associated with an increased risk for tooth failure (p = 0.02).<br />Conclusions: Females with HNC have lower stimulated whole salivary flow than males, before and after RT. Low salivary flow after RT may be a risk factor for tooth failure among females. The lower pre-RT salivary flow rates in females, combined with prior literature in other populations, indicates that, in general, females have lower stimulated salivary flow than males.<br /> (© 2024 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1601-0825
- Database :
- MEDLINE
- Journal :
- Oral diseases
- Publication Type :
- Academic Journal
- Accession number :
- 39005202
- Full Text :
- https://doi.org/10.1111/odi.15068