Synthesis and antiproliferative activity of CBD aromatic ester derivatives.

Authors :: Li K
Ge X
Lv X
Huang L
Zeng J
Cheng P
Source :: Natural product research [Nat Prod Res] 2024 Jul 14, pp. 1-7. Date of Electronic Publication: 2024 Jul 14.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: This study involved the synthesis of a series of novel cannabidiol (CBD) aromatic ester derivatives, including CBD-8,12-diaromaticester derivatives (compounds 2a-2t ) and CBD-8,12-diacetyl-21-aromaticester derivatives (compound 5a-5c ). The antiproliferative activities of these compounds against human liver cancer cell lines HePG2 and HeP3B as well as human pancreatic cancer cell lines ASPC-1 and BXPC-3 were evaluated in vitro using the CCK-8 assay. The results indicated that compound 2f exhibited an IC <subscript>50</subscript> value of 2.75 µM against HePG2, which is 5.32-fold higher than that of CBD. Additionally, compounds 2b and 5b demonstrated varying degrees of improved anticancer activity (IC <subscript>50</subscript> 5.95-9.21 µM) against HePG2.