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Tenuazonic acid-induced mycotoxicosis in an immunosuppressed mouse model and its prophylaxis with cinnamaldehyde.
- Source :
-
Chemosphere [Chemosphere] 2024 Sep; Vol. 363, pp. 142812. Date of Electronic Publication: 2024 Jul 14. - Publication Year :
- 2024
-
Abstract
- Patients with impaired immune systems are particularly vulnerable to infections. With the increasing number of immunocompromised patients, it becomes necessary to design studies that evaluate the effects of toxic contaminants that are a part of our daily lives. Simultaneously, the management of these toxic components also becomes essential. Therefore, the present study evaluated the possible protective role of cinnamaldehyde (Cin) against tenuazonic acid-induced mycotoxicosis in the immunosuppressed murine model. Tenuazonic acid (TeA), a toxin usually produced by Alternaria species, is a common contaminant in tomato and tomato-based products. Evaluating the potential toxicity of a hazardous chemical necessitates the use of in vitro, in vivo, and in silico methods. Here, the immunomodulatory effect of TeA was assessed in vitro using mouse splenocytes. In silico docking was carried out for the tumour markers of eight organs and TeA. The haematological, histopathological, and biochemical aspects were analysed in vivo. The sub-chronic intoxication of mice with TeA showed elevated malondialdehyde, reduced catalase, and superoxide dismutase production, along with abnormal levels of aspartate aminotransferase and alanine transaminase. The treatment with Cin prevented TeA-induced alterations of antioxidant defense enzyme activities and significantly forbade TeA-induced organ damage, showing therapeutic effects and toxicity reduction in TeA-induced mycotoxicosis.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Mice
Disease Models, Animal
Superoxide Dismutase metabolism
Catalase metabolism
Male
Immunocompromised Host
Malondialdehyde metabolism
Molecular Docking Simulation
Alternaria
Antioxidants pharmacology
Antioxidants metabolism
Acrolein analogs & derivatives
Acrolein toxicity
Acrolein pharmacology
Acrolein chemistry
Tenuazonic Acid pharmacology
Mycotoxicosis prevention & control
Mycotoxicosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1298
- Volume :
- 363
- Database :
- MEDLINE
- Journal :
- Chemosphere
- Publication Type :
- Academic Journal
- Accession number :
- 39004150
- Full Text :
- https://doi.org/10.1016/j.chemosphere.2024.142812