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Aberrant brain functional connectivity mediates the effects of negative symptoms on cognitive function in schizophrenia: A structural equation model.
- Source :
-
Journal of psychiatric research [J Psychiatr Res] 2024 Sep; Vol. 177, pp. 109-117. Date of Electronic Publication: 2024 Jul 04. - Publication Year :
- 2024
-
Abstract
- Background: Schizophrenia is a severe psychiatric disorder, characterized by positive symptoms, negative symptoms, and cognitive deficits. Elucidating the mechanism of negative symptom and cognitive deficits could contribute to the treatment and prognosis of schizophrenia. We hypothesized that abnormal functional connectivity would be involved in the indirect effects of negative symptoms on cognitive function.<br />Methods: A total of 150 schizophrenia male patients and 108 healthy controls matched for age, education and gender were enrolled in the study. The scores of Brief Negative Symptom Scale were divided into two factors: motivation and pleasure deficits (MAP) and diminished expression (EXP). Subsequently, a series of classic neurocognitive tests were used to evaluate cognitive functions. Resting-state fMRI data was collected from all participants. The Anatomical Automatic Labeling template was employed to establish regions of interest, thereby constructing the functional connectivity network across the entire brain. Eventually, scores of patients' negative symptoms scale, cognitive function, and strengths of abnormal functional connectivity were incorporated into a structural equation model to explore the interactions among variables.<br />Results: MAP exhibited a distinctly and significantly negative impact on cognitive function. The functional connectivity between the left insula and left precuneus, along with that between the left precuneus and right angular gyrus, collectively served as intermediaries, contributing to the indirect effects of MAP and EXP on cognitive function.<br />Conclusions: Our findings demonstrated the moderating role of aberrant brain functional connectivity between negative symptoms and cognitive function, providing clues about the neural correlates of negative symptoms and cognitive deficits in schizophrenia.<br />Competing Interests: Declaration of competing interest None to declare.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Male
Adult
Young Adult
Nerve Net diagnostic imaging
Nerve Net physiopathology
Brain physiopathology
Brain diagnostic imaging
Motivation physiology
Schizophrenia physiopathology
Schizophrenia diagnostic imaging
Schizophrenia complications
Magnetic Resonance Imaging
Cognitive Dysfunction physiopathology
Cognitive Dysfunction diagnostic imaging
Cognitive Dysfunction etiology
Connectome
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1379
- Volume :
- 177
- Database :
- MEDLINE
- Journal :
- Journal of psychiatric research
- Publication Type :
- Academic Journal
- Accession number :
- 39004002
- Full Text :
- https://doi.org/10.1016/j.jpsychires.2024.07.006