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Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.
- Source :
-
Scientific reports [Sci Rep] 2024 Jul 13; Vol. 14 (1), pp. 16215. Date of Electronic Publication: 2024 Jul 13. - Publication Year :
- 2024
-
Abstract
- The Apple polysaccharides (AP), extracted from the fruit of apple, has been used to treat multiple pathological diseases. In this study, we evaluated the effects of AP on cognitive impairment and intestinal aging in naturally aging mice. As a result, it was found that AP could improve spatial learning and memory impairment in aging mice through the Morris water maze experiment. Additionally, AP intervention can upregulate the expression of nerve growth factor (BDNF), postsynaptic marker (PSD95), and presynaptic marker (SYP) proteins. Moreover, AP can enhance total antioxidant capacity, reduce the level of pro-inflammatory cytokine, and inhibit the activation of the NF-κB signaling pathway, exerting anti-inflammatory and antioxidant functions. And the administration of AP restored intestinal mucosal barrier function, reduced the expression of aging and apoptosis related proteins. The administration of AP also altered the gut microbiota of mice. At the genus level, AP decreased the abundance of Helicobacter and Bilophila, while increased the abundance of Lactobacillus and Bacteroides. In summary, these data demonstrate that AP treatment can alleviate cognitive impairment, oxidative stress, and inflammatory reactions, repair the intestinal mucosal barrier, reduce intestinal aging, and alter specific microbial characteristics, ultimately improving the health of the elderly.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Mice
Male
Oxidative Stress drug effects
Intestinal Mucosa metabolism
Intestinal Mucosa drug effects
Maze Learning drug effects
Mice, Inbred C57BL
Intestines drug effects
Intestines microbiology
Brain metabolism
Brain drug effects
Polysaccharides pharmacology
Gastrointestinal Microbiome drug effects
Malus chemistry
Cognitive Dysfunction drug therapy
Cognitive Dysfunction metabolism
Aging drug effects
Brain-Gut Axis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39003416
- Full Text :
- https://doi.org/10.1038/s41598-024-67132-4