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Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil.
- Source :
-
Mycopathologia [Mycopathologia] 2024 Jul 14; Vol. 189 (4), pp. 66. Date of Electronic Publication: 2024 Jul 14. - Publication Year :
- 2024
-
Abstract
- Cat-transmitted sporotrichosis is caused by the emerging fungal pathogen Sporothrix brasiliensis and constitutes a significant public health issue that affects people living in resource-poor urban centers in Brazil. The lack of knowledge about transmission dynamics makes it difficult to propose public health policies to contain the advance of sporotrichosis. We describe the recent emergence of 1,176 cases of sporotrichosis in cats (2016 to 2021) in the metropolitan region of Recife, Brazil, leading to significant zoonotic transmission and an overwhelming occurrence of S. brasiliensis as the etiological agent. Most cases were from cats in the cities of Olinda (408/1,176; 34.70%), Jaboatão dos Guararapes (332/1,176; 28.23%), and Recife (237/1,176; 20.15%). Molecular typing using amplified fragment length polymorphism (EcoRI-GA/MseI-AG) revealed low polymorphic information content (PIC = 0.2499) and heterozygosity (H = 0.2928), typical of an outbreak scenario. Dendrogram and multivariate cluster analysis revealed that isolates from Pernambuco are closely related to Rio de Janeiro isolates. We report a substantial occurrence of MAT1-2 idiomorphs in the metropolitan region of Recife (0:60 ratio; χ <superscript>2</superscript> = 60.000, P < 0.0001). The limited population differentiation and genetic diversity of the isolates from Pernambuco suggest a recent introduction, possibly via a founder effect, from the parental population in Rio de Janeiro. Our findings emphasize the critical importance of molecular surveillance of S. brasiliensis for outbreak response. A comprehensive one-health strategy is mandatory to control the spread of cat-transmitted sporotrichosis driven by S. brasiliensis, encompassing sanitary barriers, quick diagnosis, and treatment.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Subjects :
- Cats
Brazil epidemiology
Animals
Molecular Typing
Zoonoses transmission
Zoonoses microbiology
Amplified Fragment Length Polymorphism Analysis
Communicable Diseases, Emerging transmission
Communicable Diseases, Emerging microbiology
Communicable Diseases, Emerging epidemiology
Genotype
Phylogeny
Sporotrichosis transmission
Sporotrichosis microbiology
Sporotrichosis veterinary
Sporotrichosis epidemiology
Sporothrix genetics
Sporothrix isolation & purification
Sporothrix classification
Cat Diseases microbiology
Cat Diseases transmission
Cat Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0832
- Volume :
- 189
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Mycopathologia
- Publication Type :
- Academic Journal
- Accession number :
- 39003373
- Full Text :
- https://doi.org/10.1007/s11046-024-00873-y