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Unraveling the molecular architecture of autoimmune thyroid diseases at spatial resolution.
- Source :
-
Nature communications [Nat Commun] 2024 Jul 13; Vol. 15 (1), pp. 5895. Date of Electronic Publication: 2024 Jul 13. - Publication Year :
- 2024
-
Abstract
- Autoimmune thyroid diseases (AITD) such as Graves' disease (GD) or Hashimoto's thyroiditis (HT) are organ-specific diseases that involve complex interactions between distinct components of thyroid tissue. Here, we use spatial transcriptomics to explore the molecular architecture, heterogeneity and location of different cells present in the thyroid tissue, including thyroid follicular cells (TFCs), stromal cells such as fibroblasts, endothelial cells, and thyroid infiltrating lymphocytes. We identify damaged antigen-presenting TFCs with upregulated CD74 and MIF expression in thyroid samples from AITD patients. Furthermore, we discern two main fibroblast subpopulations in the connective tissue including ADIRF <superscript>+</superscript> myofibroblasts, mainly enriched in GD, and inflammatory fibroblasts, enriched in HT patients. We also demonstrate an increase of fenestrated PLVAP <superscript>+</superscript> vessels in AITD, especially in GD. Our data unveil stromal and thyroid epithelial cell subpopulations that could play a role in the pathogenesis of AITD.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Fibroblasts metabolism
Fibroblasts pathology
Histocompatibility Antigens Class II metabolism
Histocompatibility Antigens Class II genetics
Thyroid Epithelial Cells metabolism
Thyroid Epithelial Cells pathology
Endothelial Cells metabolism
Endothelial Cells pathology
Transcriptome
Myofibroblasts metabolism
Myofibroblasts pathology
Stromal Cells metabolism
Stromal Cells pathology
Female
Macrophage Migration-Inhibitory Factors
Intramolecular Oxidoreductases
Graves Disease pathology
Graves Disease immunology
Graves Disease genetics
Graves Disease metabolism
Thyroid Gland pathology
Thyroid Gland metabolism
Hashimoto Disease pathology
Hashimoto Disease immunology
Hashimoto Disease metabolism
Hashimoto Disease genetics
Antigens, Differentiation, B-Lymphocyte metabolism
Antigens, Differentiation, B-Lymphocyte genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 39003267
- Full Text :
- https://doi.org/10.1038/s41467-024-50192-5