The impact of consanguinity on the design of iPSC banks.

Authors :: Alkuraya IF
De Vol EB
Source :: Stem cell reports [Stem Cell Reports] 2024 Aug 13; Vol. 19 (8), pp. 1043-1047. Date of Electronic Publication: 2024 Jul 11.
Publication Year :: 2024
Abstract: The effect of consanguinity on identifying universal induced pluripotent stem cell (iPSC) donors, i.e., homozygous for the major human leukocyte antigen (HLA) loci, is unknown. The discovery sample size was calculated in a consanguineous population using a method (1qF) based on the inbreeding coefficient. The result was orders of magnitude smaller compared to the standard method.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)