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SARS-CoV-2 serosurvey across multiple waves of the COVID-19 pandemic in New York City between 2020-2023.
- Source :
-
Nature communications [Nat Commun] 2024 Jul 11; Vol. 15 (1), pp. 5847. Date of Electronic Publication: 2024 Jul 11. - Publication Year :
- 2024
-
Abstract
- Sero-monitoring provides context to the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and changes in population immunity following vaccine introduction. Here, we describe results of a cross-sectional hospital-based study of anti-spike seroprevalence in New York City (NYC) from February 2020 to July 2022, and a follow-up period from August 2023 to October 2023. Samples from 55,092 individuals, spanning five epidemiological waves were analyzed. Prevalence ratios (PR) were obtained using Poisson regression. Anti-spike antibody levels increased gradually over the first two waves, with a sharp increase during the 3rd wave coinciding with SARS-CoV-2 vaccination in NYC resulting in seroprevalence levels >90% by July 2022. Our data provide insights into the dynamic changes in immunity occurring in a large and diverse metropolitan community faced with a new viral pathogen and reflects the patterns of antibody responses as the pandemic transitions into an endemic stage.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
New York City epidemiology
Seroepidemiologic Studies
Male
Female
Adult
Middle Aged
Aged
Cross-Sectional Studies
Young Adult
Adolescent
Child
Pandemics
Child, Preschool
Infant
Aged, 80 and over
COVID-19 Vaccines immunology
COVID-19 epidemiology
COVID-19 immunology
Antibodies, Viral blood
Antibodies, Viral immunology
SARS-CoV-2 immunology
SARS-CoV-2 isolation & purification
Spike Glycoprotein, Coronavirus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 38992013
- Full Text :
- https://doi.org/10.1038/s41467-024-50052-2