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Divergent effects of emm types 1 and 12 on invasive group A streptococcal infections-results of a retrospective cohort study, Germany 2023.
- Source :
-
Journal of clinical microbiology [J Clin Microbiol] 2024 Aug 14; Vol. 62 (8), pp. e0063724. Date of Electronic Publication: 2024 Jul 11. - Publication Year :
- 2024
-
Abstract
- As a potential side effect of the severe acute respiratory syndrome coronavirus type 2 pandemic, invasive group A Streptococcus (iGAS) infections in Europe have increased dramatically in both children and adults in the end of 2022. This epidemiological and molecular study describes the distributions of streptococcal genes encoding the M antigen ( emm types) and superantigens in patients with invasive and non-invasive GAS infections. From December 2022 to December 2023, a total of 163 GAS isolates were collected from sterile and non-sterile sites of patients at five hospitals in Germany including two tertiary care centers. Genes encoding M protein and superantigens were determined following the guidelines of CDC Streptococcus laboratory. Patients' characteristics were reviewed retrospectively. Correlations of clinical factors, emm types, and superantigens with rates of invasive infections were analyzed. Of the 163 included GAS cases, 112 (69%) were considered as invasive. In total, 33 different emm types were observed, of which emm1.0 ( n = 49; 30%), emm89.0 ( n = 15; 9%), and emm12.0 ( n = 14; 9%) were most prevalent. In total, 70% of emm1.0 isolates belonged to M1 <subscript>UK</subscript> lineage. No difference in invasive infections was observed for the M1 <subscript>UK</subscript> lineage compared with other emm1.0 isolates. However, the emm1.0 type, presence of speA1-3 , speG , or speJ , as well as adulthood were significantly associated with invasive infections. In contrast, emm12.0 isolates were significantly less associated with invasive infections. Multivariable analysis confirmed a significant influence of speJ and adulthood on iGAS infections. This study underlines the importance of continuous monitoring of genomic trends and identification of emerging GAS variants. This may aid in delineating pathogenicity factors of Streptococcus pyogenes that propel invasive infections.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Humans
Germany epidemiology
Retrospective Studies
Adult
Female
Male
Middle Aged
Child
Adolescent
Child, Preschool
Aged
Young Adult
Infant
Superantigens genetics
Aged, 80 and over
Streptococcal Infections microbiology
Streptococcal Infections epidemiology
Streptococcus pyogenes genetics
Streptococcus pyogenes classification
Streptococcus pyogenes isolation & purification
Bacterial Outer Membrane Proteins genetics
Antigens, Bacterial genetics
Carrier Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-660X
- Volume :
- 62
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of clinical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 38990040
- Full Text :
- https://doi.org/10.1128/jcm.00637-24