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Epithelial responses to fungal pathogens.
- Source :
-
Current opinion in microbiology [Curr Opin Microbiol] 2024 Aug; Vol. 80, pp. 102508. Date of Electronic Publication: 2024 Jul 10. - Publication Year :
- 2024
-
Abstract
- Epithelial cells orchestrate immune responses against fungal pathogens. This review highlights advances in integrating epithelial cells in immune responses against inhaled molds and dimorphic fungi, and against Candida species that colonize mucosal surfaces. In the lung, epithelial cells respond to interleukin-1 (IL-1) and interferon signaling to regulate effector cell influx and fungal killing. In the alimentary and vulvovaginal tracts, epithelial cells modulate fungal commensalism, invasive growth, and local immune tone, in part by responding to damage caused by candidalysin, a C. albicans peptide toxin, and through IL-17-dependent release of antimicrobial peptides that contribute to Candida colonization resistance. Understanding fungal-epithelial interactions in mammalian models of disease is critical to predict vulnerabilities and to identify opportunities for immune-based strategies to treat fungal infections.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Animals
Candidiasis immunology
Candidiasis microbiology
Fungi immunology
Fungi physiology
Fungi pathogenicity
Candida immunology
Candida physiology
Host-Pathogen Interactions immunology
Candida albicans immunology
Candida albicans physiology
Fungal Proteins metabolism
Fungal Proteins genetics
Fungal Proteins immunology
Epithelial Cells microbiology
Epithelial Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0364
- Volume :
- 80
- Database :
- MEDLINE
- Journal :
- Current opinion in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 38986398
- Full Text :
- https://doi.org/10.1016/j.mib.2024.102508