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Downregulation of hsa-miR-132 and hsa-miR-129: non-coding RNA molecular signatures of Alzheimer's disease.

Authors :
Nagaraj S
Quintanilla-Sánchez C
Ando K
Lopez-Gutierrez L
Doeraene E
Kosa AC
Aydin E
Brion JP
Leroy K
Source :
Frontiers in molecular neuroscience [Front Mol Neurosci] 2024 Jun 25; Vol. 17, pp. 1423340. Date of Electronic Publication: 2024 Jun 25 (Print Publication: 2024).
Publication Year :
2024

Abstract

Alzheimer's disease (AD) affects the elderly population by causing memory impairments, cognitive and behavioral abnormalities. Currently, no curative treatments exist, emphasizing the need to explore therapeutic options that modify the progression of the disease. MicroRNAs (miRNAs), as non-coding RNAs, demonstrate multifaceted targeting potential and are known to be dysregulated in AD pathology. This mini review focuses on two promising miRNAs, hsa-miR-132 and hsa-miR-129, which consistently exhibit differential regulation in AD. By employing computational predictions and referencing published RNA sequencing dataset, we elucidate the intricate miRNA-mRNA target relationships associated with hsa-miR-132 and hsa-miR-129. Our review consistently identifies the downregulation of hsa-miR-132 and hsa-miR-129 in AD brains as a non-coding RNA molecular signature across studies conducted over the past 15 years in AD research.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Nagaraj, Quintanilla-Sánchez, Ando, Lopez-Gutierrez, Doeraene, Kosa, Aydin, Brion and Leroy.)

Details

Language :
English
ISSN :
1662-5099
Volume :
17
Database :
MEDLINE
Journal :
Frontiers in molecular neuroscience
Publication Type :
Academic Journal
Accession number :
38984196
Full Text :
https://doi.org/10.3389/fnmol.2024.1423340