Back to Search
Start Over
Helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2024 Jun 28; Vol. 30 (24), pp. 3076-3085. - Publication Year :
- 2024
-
Abstract
- Background: Helicobacter pylori (H. pylori) infection is closely associated with gastrointestinal diseases. Our preliminary studies have indicated that H. pylori infection had a significant impact on the mucosal microbiome structure in patients with gastric ulcer (GU) or duodenal ulcer (DU).<br />Aim: To investigate the contributions of H . pylori infection and the mucosal microbiome to the pathogenesis and progression of ulcerative diseases.<br />Methods: Patients with H . pylori infection and either GU or DU, and healthy individuals without H . pylori infection were included. Gastric or duodenal mucosal samples was obtained and subjected to metagenomic sequencing. The compositions of the microbial communities and their metabolic functions in the mucosal tissues were analyzed.<br />Results: Compared with that in the healthy individuals, the gastric mucosal microbiota in the H . pylori -positive patients with GU was dominated by H . pylori , with significantly reduced biodiversity. The intergroup differential functions, which were enriched in the H . pylori -positive GU patients, were all derived from H . pylori , particularly those concerning transfer RNA queuosine-modification and the synthesis of demethylmenaquinones or menaquinones. A significant enrichment of the uibE gene was detected in the synthesis pathway. There was no significant difference in microbial diversity between the H. pylori -positive DU patients and healthy controls.<br />Conclusion: H . pylori infection significantly alters the gastric microbiota structure, diversity, and biological functions, which may be important contributing factors for GU.<br />Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.<br /> (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Case-Control Studies
Aged
Metagenomics methods
Duodenum microbiology
Dysbiosis microbiology
Helicobacter Infections microbiology
Helicobacter pylori isolation & purification
Helicobacter pylori genetics
Duodenal Ulcer microbiology
Duodenal Ulcer diagnosis
Gastric Mucosa microbiology
Gastric Mucosa pathology
Gastrointestinal Microbiome
Stomach Ulcer microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 30
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 38983956
- Full Text :
- https://doi.org/10.3748/wjg.v30.i24.3076