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Analysis of cancer-specific survival in patients with metastatic colorectal cancer: A evidence-based medicine study.
Analysis of cancer-specific survival in patients with metastatic colorectal cancer: A evidence-based medicine study.
- Source :
-
World journal of gastrointestinal surgery [World J Gastrointest Surg] 2024 Jun 27; Vol. 16 (6), pp. 1791-1802. - Publication Year :
- 2024
-
Abstract
- Background: Metastatic colorectal cancer (mCRC) is a common malignancy whose treatment has been a clinical challenge. Cancer-specific survival (CSS) plays a crucial role in assessing patient prognosis and treatment outcomes. However, there is still limited research on the factors affecting CSS in mCRC patients and their correlation.<br />Aim: To predict CSS, we developed a new nomogram model and risk grading system to classify risk levels in patients with mCRC.<br />Methods: Data were extracted from the United States Surveillance, Epidemiology, and End Results database from 2018 to 2023. All eligible patients were randomly divided into a training cohort and a validation cohort. The Cox proportional hazards model was used to investigate the independent risk factors for CSS. A new nomogram model was developed to predict CSS and was evaluated through internal and external validation.<br />Results: A multivariate Cox proportional risk model was used to identify independent risk factors for CSS. Then, new CSS columns were developed based on these factors. The consistency index (C-index) of the histogram was 0.718 (95%CI: 0.712-0.725), and that of the validation cohort was 0.722 (95%CI: 0.711-0.732), indicating good discrimination ability and better performance than tumor-node-metastasis staging (C-index: 0.712-0.732). For the training set, 0.533, 95%CI: 0.525-0.540; for the verification set, 0.524, 95%CI: 0.513-0.535. The calibration map and clinical decision curve showed good agreement and good potential clinical validity. The risk grading system divided all patients into three groups, and the Kaplan-Meier curve showed good stratification and differentiation of CSS between different groups. The median CSS times in the low-risk, medium-risk, and high-risk groups were 36 months (95%CI: 34.987-37.013), 18 months (95%CI: 17.273-18.727), and 5 months (95%CI: 4.503-5.497), respectively.<br />Conclusion: Our study developed a new nomogram model to predict CSS in patients with synchronous mCRC. In addition, the risk-grading system helps to accurately assess patient prognosis and guide treatment.<br />Competing Interests: Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.<br /> (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1948-9366
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- World journal of gastrointestinal surgery
- Publication Type :
- Academic Journal
- Accession number :
- 38983329
- Full Text :
- https://doi.org/10.4240/wjgs.v16.i6.1791