Back to Search
Start Over
Dual-Targeted Zeolitic Imidazolate Frameworks Drug Delivery System Reversing Cisplatin Resistance to Treat Resistant Ovarian Cancer.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2024 Jul 03; Vol. 19, pp. 6603-6618. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Objective: Ovarian cancer cells are prone to acquire tolerance to chemotherapeutic agents, which seriously affects clinical outcomes. The development of novel strategies to enhance the targeting of chemotherapeutic agents to overcome drug resistance and minimize side effects is significant for improving the clinical outcomes of ovarian cancer patients.<br />Methods: We employed folic acid (FA)-modified ZIF-90 nanomaterials (FA-ZIF-90) to deliver the chemotherapeutic drug, cisplatin (DDP), via dual targeting to improve its targeting to circumvent cisplatin resistance in ovarian cancer cells, especially by targeting mitochondria. FA-ZIF-90/DDP could rapidly release DDP in response to dual stimulation of acidity and ATP in tumor cells.<br />Results: FA-ZIF-90/DDP showed good blood compatibility. It was efficiently taken up by human ovarian cancer cisplatin-resistant cells A2780/DDP and aggregated in the mitochondrial region. FA-ZIF-90/DDP significantly inhibited the mitochondrial activity and metastatic ability of A2780/DDP cells. In addition, it effectively induced apoptosis in A2780/DDP cells and overcame cisplatin resistance. In vivo experiments showed that FA-ZIF-90/DDP increased the accumulation of DDP in tumor tissues and significantly inhibited tumor growth.<br />Conclusion: FA-modified ZIF-90 nanocarriers can improve the tumor targeting and anti-tumor effects of chemotherapeutic drugs, reduce toxic side effects, and are expected to be a novel therapeutic strategy to reverse drug resistance in ovarian cancer.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2024 Xing et al.)
- Subjects :
- Female
Humans
Animals
Cell Line, Tumor
Drug Delivery Systems methods
Mitochondria drug effects
Mice
Mice, Inbred BALB C
Mice, Nude
Drug Carriers chemistry
Metal-Organic Frameworks chemistry
Metal-Organic Frameworks pharmacology
Xenograft Model Antitumor Assays
Cisplatin pharmacology
Cisplatin chemistry
Cisplatin pharmacokinetics
Ovarian Neoplasms drug therapy
Ovarian Neoplasms pathology
Drug Resistance, Neoplasm drug effects
Zeolites chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents administration & dosage
Folic Acid chemistry
Folic Acid pharmacology
Imidazoles chemistry
Imidazoles pharmacology
Imidazoles administration & dosage
Apoptosis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 19
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 38979533
- Full Text :
- https://doi.org/10.2147/IJN.S434950