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Metabolic vulnerabilities in cancer: A new therapeutic strategy.

Authors :
El-Tanani M
Rabbani SA
El-Tanani Y
Matalka II
Source :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Sep; Vol. 201, pp. 104438. Date of Electronic Publication: 2024 Jul 06.
Publication Year :
2024

Abstract

Cancer metabolism is now a key area for therapeutic intervention, targeting unique metabolic reprogramming crucial for tumor growth and survival. This article reviews the therapeutic potential of addressing metabolic vulnerabilities through glycolysis and glutaminase inhibitors, which disrupt cancer cell metabolism. Challenges such as tumor heterogeneity and adaptive resistance are discussed, with strategies including personalized medicine and predictive biomarkers to enhance treatment efficacy. Additionally, integrating diet and lifestyle changes with metabolic targeting underscores a holistic approach to improving therapy outcomes. The article also examines the benefits of incorporating these strategies into standard care, highlighting the potential for more tailored, safer treatments. In conclusion, exploiting metabolic vulnerabilities promises a new era in oncology, positioning metabolic targeting at the forefront of personalized cancer therapy and transforming patient care.<br />Competing Interests: Declaration of Competing Interest The authors have no conflict of interests to declare<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0461
Volume :
201
Database :
MEDLINE
Journal :
Critical reviews in oncology/hematology
Publication Type :
Academic Journal
Accession number :
38977145
Full Text :
https://doi.org/10.1016/j.critrevonc.2024.104438