Photoredox-Catalyzed Sequential Decarboxylative/Defluorinative Aminoalkylation of CF 3 -Alkenes with N -Arylglycines.

A photoredox-catalyzed sequential decarboxylative/defluorinative aminoalkylation of CF ₃ -alkenes with N -arylglycines is described. This metal-free and redox-neutral protocol provided efficient access to the monofluoroalkenyl-1,5-diamines in good yields with excellent functional group compatibility. Mechanistic studies revealed that the reaction proceeds via a radical pathway with the gem -difluoroalkenyl amine as an intermediate.