An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial-an update to the published protocol.

Authors :: Randremanana RV
Raberahona M
de Dieu Randria MJ
Bourner J
Zadonirina G
Razananaivo H
Mayouya-Gamana T
Mangahasimbola R
Pesonel E
Gillesen A
Rajerison M
Andrianaivoarimanana V
Edwards T
Horby P
Olliaro P
Source :: Trials [Trials] 2024 Jul 05; Vol. 25 (1), pp. 457. Date of Electronic Publication: 2024 Jul 05.
Publication Year :: 2024
Abstract: This article reports an update to the protocol of the IMASOY trial, which was prospectively registered on clinicaltrials.gov (NCT04110340) in October 2019.<br /> (© 2024. The Author(s).)

Subjects :: Treatment Outcome
Humans
Plague drug therapy
Randomized Controlled Trials as Topic
Equivalence Trials as Topic
Drug Therapy, Combination
Animals
Aminoglycosides adverse effects
Aminoglycosides administration & dosage
Aminoglycosides therapeutic use
Ciprofloxacin adverse effects
Ciprofloxacin administration & dosage
Ciprofloxacin therapeutic use
Anti-Bacterial Agents adverse effects
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use

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